Abstract
Starting with the weak agonist indomethacin, a series of potent, selective CRTh2 (DP(2)) antagonists have been discovered as potential treatments for asthma, allergic rhinitis and other inflammatory diseases.
MeSH terms
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Asthma / drug therapy*
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Chemistry, Pharmaceutical
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Drug Design
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Humans
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Indomethacin / pharmacology*
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Inflammation / drug therapy*
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Inhibitory Concentration 50
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Models, Chemical
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Protein Binding
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Receptors, Immunologic / antagonists & inhibitors*
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Receptors, Prostaglandin / antagonists & inhibitors*
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Receptors, Prostaglandin / metabolism
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Rhinitis / drug therapy*
Substances
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Receptors, Immunologic
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Receptors, Prostaglandin
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Indomethacin
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prostaglandin D2 receptor